These are not all of the potential important safety considerations for EXPAREL, please see the full Prescribing Information.
Innovative DepoFoam Technology Delivers Bupivacaine Over Time
Pacira Pharmaceuticals, Inc., makers of EXPAREL®, own the proven product delivery technology, DepoFoam. DepoFoam has been used safely in two other products, and has a demonstrated safety record and history of regulatory approvals in the United States, Europe, and several other countries around the world.
- EXPAREL uses DepoFoam, a multivesicular liposomal drug delivery technology, to encapsulate bupivacaine
- Following injection, bupivacaine is released over time as the DepoFoam lipid membranes erode and reorganize
- In EXPAREL, DepoFoam is <3% lipid, biodegradable, and biocompatible
How it Works
The DepoFoam carrier matrix is made up of microscopic, polyhedral particles composed of numerous, non-concentric, internal aqueous chambers that encapsulate drugs without altering their molecular structure and then release them over a desired period of time. Each chamber is separated from adjacent chambers by lipid membranes. Following injection, the DepoFoam particles release medication over time due to erosion and/or reorganization of the lipid membranes.
DepoFoam-based drugs are formulated as ready-to-use, aqueous suspensions allowing for simple injection through needles with a bore size as narrow as 25 gauge.