Calendar of Events

Congress of Neurological Surgeons (CNS)
Spine Summit 2017
33rd Annual Meeting of the Section on Disorders of the Spine and Peripheral News
March 8-11, 2017
Las Vegas, NV
www.cns.org

33rd Annual Miami Breast Cancer Conference
March 9-12, 2017
Miami Beach, FL
www.gotoper.com

Society of Gynocologic Oncology (SGO)
Annual Meeting on Women’s Cancer
March 13-14, 2017
National Harbor, MD
www.sgo.org

American Academy of Orthopedic Surgeons (AAOS)
2017 Annual Meeting
March 14-18, 2017
San Diego, CA
www.aaos.org

Academy of Osseointegration (AO)
2017 Annual Meeting
March 15-18, 2017
Orlando, FL
www.osseo.org

Society of American Gastrointestinal and Endoscopic Surgeons (SAGES)
SAGES 2017 Annual Meeting
March 22-25
Houston, TX
www.sages2017.org

Annual Regional Anesthesiology and Acute Pain Medicine (ASRA)
Spring Meeting
April 6-8, 2017
San Francisco, CA
www.asra.com

Health Connect Partners
Hospital Pharmacy Conference
May 1-3, 2017
Los Angeles, CA
www.hlthcp.com

American College of Oral and Maxillofacial Surgeons (ACOMS)
ACOMS and CAOMS Joint Annual Conference and Exhibition
May 3-5, 2017
Vancouver, BC
www.acoms.org

Society of Ambulatory Anesthesia (SAMBA)
32nd Annual Meeting
May 4-6, 2017
Scottsdale, AZ
www.sambahq.org

American Society of Colon & Rectal Surgeons (ASCRS)
Annual Scientific Meeting
June 10-14, 2017
Seattle, WA
https://www.fascrs.org/2017-annual-scientific-meeting

Society for Minimally Invasive Spine Surgery (SMISS)
Annual Forum
September 14-16, 2017
Las Vegas, NV
www.smiss.org

New York School of Regional Anesthesia (NYSORA)
16th Annual Symposium on Regional Anesthesia, Pain, and Perioperative Medicine
September 23-24, 2017
www.nysora.com

American Society of Plastic Surgeons (ASPS)
The Meeting
October 6-10, 2017
Orlando, FL
www.plasticsurgery.org

American Association Oral and Maxillofacial Surgeons (AAOMS)
99th Annual Meeting, Scientific Sessions, and Exhibition
October 9-14, 2017
San Francisco, CA
www.aaoms.org

Health Connect Partners
HCP Reverse EXPO
October 16-18, 2017
Chicago, IL
https://www.hlthcp.com/

American Society of Anesthesiologists (ASA)
Anesthesiology 2017
October 21-25, 2017
Boston, MA
www.asahq.org

American College of Surgeons (ACS)
Clinical Congress
October 22-26, 2017
San Diego, CA
www.facs.org

North American Spine Society (NASS)
Annual Meeting
October 25-28, 2017
Orlando, FL
www.spine.org

American Society for Metabolic and Bariatric Surgery (ASMBS)
34th Annual Meeting at Obesity Week
October 29-November 2, 2017
Washington, DC
www.asmbs.org

American Association of Hip and Knee Surgeons (AAHKS)
2017 Annual Meeting
November 2-5, 2017
Dallas, TX
www.aahks.net

Current Concepts in Joint Replacement (CCJR)
Winter 2017 Meeting
December 13-16, 2017
Orlando, FL
www.ccjr.com

If You Are a Patient

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EXPAREL in Oral Surgery

Find information on using EXPAREL for local infiltration in oral surgery.

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Important Notice

This site is for informational purposes only and is intended to address medical questions from healthcare professionals in the United States.

To report an adverse event, e-mail drugsafety@pacira.com or dial 1-855-RX-EXPAREL (1-855-793-9727).

For medical inquiries related to EXPAREL, submit a request to Medical Information or call 1-855-RX-EXPAREL (1-855-793-9727).

These are not all of the potential important safety considerations for EXPAREL; please see the full Prescribing Information.

Important Safety Information

Warnings and Precautions Specific to EXPAREL

Warnings and Precautions for Bupivacaine-Containing Products

Please refer to full Prescribing Information.

Important Safety Information

Medical Information

US healthcare professionals Click Here

Non-US healthcare professionals can submit a request to medinfo@pacira.com

If you are not a healthcare professional, please discuss any questions you have regarding your health or treatment with your physician, pharmacist, nurse, or other healthcare professional.

Important information about EXPAREL®

The FDA confirms that EXPAREL has always been approved for "administration into the surgical site to produce postsurgical analgesia" for use in a variety of surgeries not limited to those studied in its pivotal trials.

"We are pleased to announce a successful collaboration with the FDA to resolve this matter in an expeditious and meaningful way that allows us to get back to the important task at hand—reducing postsurgical opioid exposure by providing a non-opioid option like EXPAREL to as many patients as appropriate."

- Dave Stack, Chief Executive Officer and Chairman of Pacira

The clinical benefit of the decrease in opioid consumption was not demonstrated in the pivotal trials.

Important Safety Information

  • EXPAREL is contraindicated in obstetrical paracervical block anesthesia
  • In clinical trials, the most common adverse reactions (incidence ≥10%) following EXPAREL administration were nausea, constipation, and vomiting
  • EXPAREL is not recommended to be used in the following patient population: patients <18 years old and/or pregnant patients
  • Because amide-type local anesthetics, such as bupivacaine, are metabolized by the liver, EXPAREL should be used cautiously in patients with hepatic disease. Patients with severe hepatic disease, because of their inability to metabolize local anesthetics normally, are at a greater risk of developing toxic plasma concentrations

Warnings and Precautions Specific to EXPAREL

  • EXPAREL is not recommended for the following types or routes of administration: epidural, intrathecal, regional nerve blocks, or intravascular or intra-articular use
  • Non-bupivacaine-based local anesthetics, including lidocaine, may cause an immediate release of bupivacaine from EXPAREL if administered together locally. The administration of EXPAREL may follow the administration of lidocaine after a delay of 20 minutes or more. Formulations of bupivacaine other than EXPAREL should not be administered within 96 hours following administration of EXPAREL

Warnings and Precautions for Bupivacaine-Containing Products

  • Central Nervous System (CNS) Reactions: There have been reports of adverse neurologic reactions with the use of local anesthetics. These include persistent anesthesia and paresthesias. CNS reactions are characterized by excitation and/or depression
  • Cardiovascular System Reactions: Toxic blood concentrations depress cardiac conductivity and excitability which may lead to dysrhythmias sometimes leading to death
  • Allergic Reactions: Allergic-type reactions (eg, anaphylaxis and angioedema) are rare and may occur as a result of hypersensitivity to the local anesthetic or to other formulation ingredients
  • Chondrolysis: There have been reports of chondrolysis (mostly in the shoulder joint) following intra-articular infusion of local anesthetics, which is an unapproved use

Please refer to full Prescribing Information.

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