Support Materials

Tools for healthcare providers using EXPAREL®

Administration Case Reports 

Administration Case Reports

View examples of how physicians are administering EXPAREL in various procedures in their practices.

EXPAREL® Fast Fact Tear Pad 

EXPAREL® Fast Fact Tear Pad

Get the facts about proper administration, storage, and handling of EXPAREL.

EXPAREL® vs Propofol 

EXPAREL® vs. Propofol

Learn about key differences in the appearance, storage, preparation, and use of EXPAREL and Propofol that help to prevent product confusion.

EXPAREL® Patient Fact Sheet 

EXPAREL® Patient Fact Sheet

Educate your patients about EXPAREL and possible side effects with this patient-friendly fact sheet.

EXPAREL® Patient Brochure 

Concerned About Pain After Surgery?

Read through a patient brochure that gives more information about how postsurgical pain can be treated.

Implementation Guide for EXPAREL® 

Implementing EXPAREL

Follow these step-by-step instructions and best practices for successful implementation and use of EXPAREL across your organization.

EXPAREL® Medicare Reimbursement Guide 

EXPAREL® Medicare Reimbursement Guide

Find helpful coding guidance for Medicare and Commercial payors.

EXPAREL® Nurse Information Sheet 

 Nurse Information Sheet

Find out what nurses need to know about using EXPAREL in postsurgical patient care.

EXPAREL® Ordering Information 

 Nurse Information Sheet

Exparel is available for order in two different doses and carton sizes.

EXPAREL® Dosing
Brochure 

Exparel Dosing Brochure

Learn more about the two doses of EXPAREL, which provide greater flexibility in small and larger surgical procedures.

Important Notice

This site is for informational purposes only and is intended to address medical questions from healthcare professionals in the United States.

To report an adverse event, e-mail drugsafety@pacira.com or dial 1-855-RX-EXPAREL (1-855-793-9727).

For medical inquiries related to EXPAREL, submit a request to Medical Information or call 1-855-RX-EXPAREL (1-855-793-9727).

These are not all of the potential important safety considerations for EXPAREL; please see the full Prescribing Information.

Important Safety Information

Warnings and Precautions Specific to EXPAREL

Warnings and Precautions for Bupivacaine-Containing Products

Please refer to full Prescribing Information.

Important Safety Information

Medical Information

US healthcare professionals Click Here

Non-US healthcare professionals can submit a request to medinfo@pacira.com

If you are not a healthcare professional, please discuss any questions you have regarding your health or treatment with your physician, pharmacist, nurse, or other healthcare professional.

Important information about EXPAREL®

The FDA confirms that EXPAREL has always been approved for "administration into the surgical site to produce postsurgical analgesia" for use in a variety of surgeries not limited to those studied in its pivotal trials.

"We are pleased to announce a successful collaboration with the FDA to resolve this matter in an expeditious and meaningful way that allows us to get back to the important task at hand—reducing postsurgical opioid exposure by providing a non-opioid option like EXPAREL to as many patients as appropriate."

- Dave Stack, Chief Executive Officer and Chairman of Pacira

The clinical benefit of the decrease in opioid consumption was not demonstrated in the pivotal trials.

Important Safety Information

  • EXPAREL is contraindicated in obstetrical paracervical block anesthesia
  • In clinical trials, the most common adverse reactions (incidence ≥10%) following EXPAREL administration were nausea, constipation, and vomiting
  • EXPAREL is not recommended to be used in the following patient population: patients <18 years old and/or pregnant patients
  • Because amide-type local anesthetics, such as bupivacaine, are metabolized by the liver, EXPAREL should be used cautiously in patients with hepatic disease. Patients with severe hepatic disease, because of their inability to metabolize local anesthetics normally, are at a greater risk of developing toxic plasma concentrations

Warnings and Precautions Specific to EXPAREL

  • EXPAREL is not recommended for the following types or routes of administration: epidural, intrathecal, regional nerve blocks, or intravascular or intra-articular use
  • Non-bupivacaine-based local anesthetics, including lidocaine, may cause an immediate release of bupivacaine from EXPAREL if administered together locally. The administration of EXPAREL may follow the administration of lidocaine after a delay of 20 minutes or more. Formulations of bupivacaine other than EXPAREL should not be administered within 96 hours following administration of EXPAREL

Warnings and Precautions for Bupivacaine-Containing Products

  • Central Nervous System (CNS) Reactions: There have been reports of adverse neurologic reactions with the use of local anesthetics. These include persistent anesthesia and paresthesias. CNS reactions are characterized by excitation and/or depression
  • Cardiovascular System Reactions: Toxic blood concentrations depress cardiac conductivity and excitability which may lead to dysrhythmias sometimes leading to death
  • Allergic Reactions: Allergic-type reactions (eg, anaphylaxis and angioedema) are rare and may occur as a result of hypersensitivity to the local anesthetic or to other formulation ingredients
  • Chondrolysis: There have been reports of chondrolysis (mostly in the shoulder joint) following intra-articular infusion of local anesthetics, which is an unapproved use

Please refer to full Prescribing Information.

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