Cesarean Section: Medical center in Texas
- Adult patients (N=201) who underwent elective, unscheduled waiting list, or emergency cesarean delivery with an EXPAREL TAP block (n=101) compared with patients who did not receive an EXPAREL TAP block (n=100)
- Retrospective chart review
- Patients treated with EXPAREL reported fewer adverse events, such as nausea, vomiting, or pruritus (34% vs 50%; P=0.026)
Clinical and Economic Outcomes
In patients who received EXPAREL for analgesia
better pain control
- 132.8 vs 246.3 (P<0.001) of total AUC of NRS pain scores from 0 to 3 days
reduction in postsurgical opioid consumption through 3 days§
- Total postsurgical opioid consumption (MED), mg: 41.9 vs 79.6 (P<0.001)
- 26% reduction in LOS (2.9 days vs 3.9 days; P<0.001)
- 19% reduction in time to discharge readiness (2.9 days vs 3.6 days; P=0.006)
reduction in PACU discharge readiness time (25 minutes)
- 138 minutes vs 163 minutes (P=0.028)
reduction in time to ambulation
- 18.7 hours vs 30.7 hours; P<0.001
*The NRS scale used ranged from 0, representing no pain, to 10, representing the worst possible pain.
§The clinical benefit of the decrease in opioid consumption was not demonstrated in the clinical trials.
AUC, area under the curve; NRS, numerical rating scale; TAP, transversus abdominis plane; LOS, length of stay; MED, morphine equivalent doses; PACU, postanesthesia care unit.