Nurse and patient smiling as patient is discharged from hospital post-nerve block surgery

Clinical and economic value outcomes with EXPAREL

Cost & Value

EXPAREL is available in 133 mg (10 mL) for $180.35 and 266 mg (20 mL) doses for $334.18. The 133 mg (10 mL) and 266 mg (20 mL) doses of EXPAREL are available in cartons of 4 and 10 vials. For more information please visit How to order EXPAREL.

Information below helps review the value of EXPAREL in a multimodal pain management protocol that can lead to fewer opioids, better pain control, and shorter length of stay (LOS). These, in turn, can lead to fewer patient complications and reduced hospital costs per patient.

Select Procedure Type
Women's Health

Gynecologic Oncology Robotic-Assisted Hysterectomy:
Medical center in Minnesota

Study Methods

  • 60 adult patients undergoing robotic-assisted hysterectomy: 30 received a transversus abdominis plane (TAP) block with EXPAREL, and 30 did not receive a TAP block
  • Retrospective observational study
  • All patients received intraoperative and postsurgical opioids

Safety Outcomes

  • 3.3% of patients in the TAP block EXPAREL group had a postsurgical complication, compared with 20% in the group of patients who did not receive a TAP block

Clinical and Economic Outcomes

Patients who received EXPAREL to manage pain after surgery had
  • Significantly

    less pain

    over first 24 hours after infiltration

    • 5 vs 7 on 11-point scale*
  • 16.2 hours

    shorter LOS

    • 11.5 vs 27.7 hours (P>0.0001)
  • 63%

    fewer occurrences
    of nausea or

    • 20% vs 53.3% (P=0.02)


  • Intraoperative and postsurgical opioid-based analgesia regimen


  • Intraoperative and postsurgical opioid-based analgesia regimen
  • A subcostal TAP block was performed under ultrasound guidance with a 22-gauge 30º beveled needle. After the needle pierced the transversus abdominis fascia, three 10-mL syringes of local anesthetic were injected. The first syringe contained 10 mL of 0.25% bupivacaine with epinephrine (1:200,000), and the other 2 syringes each contained 5 mL of EXPAREL and 5 mL of 0.9% preservative-free normal saline
    • This process was repeated on the contralateral side

*Difference in pain scores remained statistically significant after adjustments for potential confounders (P=0.004).

The use of EXPAREL in combination with epinephrine is not part of the approved label.