Nurse and patient smiling as patient is discharged from hospital post-nerve block surgery

Clinical and economic value outcomes with EXPAREL

Cost & Value

EXPAREL is available in 133 mg (10 mL) for $180.35 and 266 mg (20 mL) doses for $334.18. The 133 mg (10 mL) and 266 mg (20 mL) doses of EXPAREL are available in cartons of 4 and 10 vials. For more information please visit How to order EXPAREL.

Information below helps review the value of EXPAREL in a multimodal pain management protocol that can lead to fewer opioids, better pain control, and shorter length of stay (LOS). These, in turn, can lead to fewer patient complications and reduced hospital costs per patient.

Total Knee Arthroplasty1: 16 US centers

Study Methods

  • 139 patients who received a TKA, with 70 receiving EXPAREL® (bupivacaine liposome injectable suspension) and 69 who did not
  • Phase 4 clinical trial

Safety Outcomes

  • Both treatments were well tolerated, with most adverse events mild or moderate. 1 patient in each group experienced a serious adverse event, with both events deemed unrelated to the study medication

Clinical and Economic Outcomes

In patients who received EXPAREL for analgesia
  • Significantly

    better pain control

    12 to 48 hours
    after surgery*

  • 78%

    reduction in opioid
    use 0 to 48 hours
    after surgery

  • 10%

    of patients
    free of opioids
    at 72 hours


TKA (N=139)

  • Preoperative regimen
    • Acetaminophen 1000 mg, celecoxib 200 mg, oral pregabalin 300 mg, and intravenous tranexamic acid 1 g within 4 hours before surgery
  • Intraoperative regimen
    • Fentanyl or its analog
  • Postsurgical regimen
    • Oral acetaminophen 975 to 1000 mg every 8 hours, oral celecoxib 200 mg every 12 hours, rescue analgesics as needed (oral immediate-release oxycodone ≤10 mg every 4 hours or as needed, intravenous morphine 2.5 to 5 mg or hydromorphone 0.5 to 1 mg every 4 hours or as needed if oral medication was not tolerated). Rescue medications were received upon patient request for analgesia


  • Local infiltration with EXPAREL 266 mg/20 mL admixed with bupivacaine HCl 0.5%, 20 mL, expanded with saline to a total volume of 120 mL


  • Local infiltration with bupivacaine HCl 0.5%, 20 mL, expanded with saline to a total volume of 120 mL

*Pain measured using visual analog scale.