EXPAREL is a cost-effective option for postsurgical pain management in the hospital and ambulatory (outpatient) settings

Cost and Value

EXPAREL is available in 133 mg (10 mL) dose for $180.35 and 266 mg (20 mL) dose for $334.18. The 133 mg (10 mL) and 266 mg (20 mL) doses of EXPAREL are available in cartons of 4 and 10 vials. For more information please visit How to order EXPAREL.

Information below helps review the value of EXPAREL in a multimodal pain management protocol that can lead to fewer opioids,* better pain control, and shorter LOS. These, in turn, can lead to fewer patient complications and reduced hospital costs per patient.

Minimally Invasive Surgery (MIS)-Transforaminal Lumbar Interbody Fusion (TLIF)1: Medical center in Florida

Study Methods

  • 38 adult patients treated with enhanced recovery protocol (ERP) after MIS TLIF were analyzed retrospectively and compared with 15 adult patients who underwent MIS TLIF before the implementation of ERP (N=53)
  • All patients underwent standard MIS TLIF, but the control group did not receive all ERP components, including EXPAREL® (bupivacaine liposome injectable suspension)

Safety Outcomes

  • The overall rate of complications was lower in the ERP group (12% versus 21%)*

Clinical and Economic Outcomes

Patients who received ERP with EXPAREL to manage pain after surgery had

  • 2.7days

    shorter length of
    stay (LOS)

    • 1.2 vs 3.9 days (P=0.009)
  • $3444

    reduction in total cost for acute-care hospitalization

    • $19,212 vs $22,656 (P<0.001)
  • 100%

    rate of
    discharge home

    • 100% vs 86%
 

STANDARD MIS TLIF (n=15)

  • Standard surgical protocol utilizing 3 out of 6 ERP components
    • Expandable cage
    • Bone morphogenetic protein
    • Small-caliber percutaneous screws
  • General anesthesia

ERP WITH EXPAREL (n=38)

  • ERP surgical protocol with all 6 components
    • Local infiltration into the surgical site with EXPAREL diluted with saline and bupivacaine hydrochloride
    • Anesthesia without intubation
    • Working channel endoscope
    • Expandable cage
    • Bone morphogenetic protein
    • Small-caliber percutaneous screws

*The statistical significance of decreased complications was not evaluated.

Areas of greatest savings included a reduction in intensive care unit costs, shorter overall LOS, and decreased costs from a reduced operating room duration.