Total Shoulder Arthroplasty or Rotator Cuff Repair: 16 international study sites
- 140 patients undergoing TSA or RCR who received EXPAREL (n=69) or placebo (n=71)
- Phase 3 clinical trial
- 4 patients (3 in the EXPAREL group and 1 in the placebo group) experienced adverse events that were deemed unrelated to the study medication
Clinical and Economic Outcomes
In patients who received EXPAREL for analgesia
better pain control
through 48 hours
- Median time to return of sensory function with EXPAREL was 36 hours, which was significantly longer than placebo (P<0.0001), and median time to return of motor function was 24 hours with both EXPAREL and placebo
reduction in opioid
use through 48 hours
of patients opioid free compared with 1% with placebo at 48 hours
*The clinical benefit of the decrease in opioid consumption was not demonstrated in the clinical trials.
RCR, rotator cuff repair; TSA, total shoulder arthroplasty.