EXPAREL is a cost-effective option for postsurgical pain management in the hospital and ambulatory (outpatient) settings

Cost and Value

EXPAREL is available in 133 mg (10 mL) dose for $180.35 and 266 mg (20 mL) dose for $334.18. The 133 mg (10 mL) and 266 mg (20 mL) doses of EXPAREL are available in cartons of 4 and 10 vials. For more information please visit How to order EXPAREL.

Information below helps review the value of EXPAREL in a multimodal pain management protocol that can lead to fewer opioids,* better pain control, and shorter LOS. These, in turn, can lead to fewer patient complications and reduced hospital costs per patient.

Shoulder Arthroplasty1: Hospital in Florida

Study Methods

  • 55 patients undergoing SA who received a standardized multi-modal pain management approach alone (n=24) or a standardized multi-modal pain management approach with EXPAREL® (bupivacaine liposome injectable suspension) and dexamethasone (n=31)
  • Retrospective cohort analysis

Clinical and Economic Outcomes

Patients who received EXPAREL and dexamethasone for analgesia had

  • Significantly less pain

    on POD 1

  • 51%

    less cumulative
    opioid use
    for all PODs

  • 50%

    reduction in LOS


SA (N=55)

  • Preoperative
    • Single-injection interscalene block with 1000 mg of intravenous acetaminophen, 600 mg of oral gabapentin, 10 mg of oral oxycodone, and 200 mg of oral celecoxib
  • Postsurgical
    • Intravenous ketorolac and acetaminophen with oral gabapentin for 24 hours after surgery
    • 5 mg and 10 mg of oxycodone for mild to moderate pain and 0.5 mg, 1 mg, and 2 mg of intravenous hydromorphone for moderate to severe pain


  • Intraoperative
    • Intravenous administration of 8 to 10 mg of dexamethasone and injection of 50 mL admixture of saline, 0.25% bupivacaine HCl with epinephrine, and EXPAREL. 20 mL of EXPAREL was diluted with 20 mL of saline and 10 mL of 0.25% bupivacaine HCl with epinephrine*

POD, postoperative day; SA, shoulder arthroplasty.

*The use of EXPAREL in combination with epinephrine is not part of the approved label.