Nurse and patient smiling as patient is discharged from hospital post-nerve block surgery

Clinical and economic value outcomes with EXPAREL

Cost & Value

EXPAREL is available in 133 mg (10 mL) for $180.35 and 266 mg (20 mL) doses for $334.18. The 133 mg (10 mL) and 266 mg (20 mL) doses of EXPAREL are available in cartons of 4 and 10 vials. For more information please visit How to order EXPAREL.

Information below helps review the value of EXPAREL in a multimodal pain management protocol that can lead to fewer opioids, better pain control, and shorter length of stay (LOS). These, in turn, can lead to fewer patient complications and reduced hospital costs per patient.

Shoulder Arthroplasty1: Hospital in Florida

Study Methods

  • 55 patients undergoing SA who received a standardized multi-modal pain management approach alone (n=24) or a standardized multi-modal pain management approach with EXPAREL® (bupivacaine liposome injectable suspension) and dexamethasone (n=31)
  • Retrospective cohort analysis

Clinical and Economic Outcomes

Patients who received EXPAREL and dexamethasone for analgesia had
  • Significantly less pain

    on POD 1

  • 51%

    less cumulative
    opioid use
    for all PODs

  • 50%

    reduction in LOS


SA (N=55)

  • Preoperative
    • Single-injection interscalene block with 1000 mg of intravenous acetaminophen, 600 mg of oral gabapentin, 10 mg of oral oxycodone, and 200 mg of oral celecoxib
  • Postsurgical
    • Intravenous ketorolac and acetaminophen with oral gabapentin for 24 hours after surgery
    • 5 mg and 10 mg of oxycodone for mild to moderate pain and 0.5 mg, 1 mg, and 2 mg of intravenous hydromorphone for moderate to severe pain


  • Intraoperative
    • Intravenous administration of 8 to 10 mg of dexamethasone and injection of 50 mL admixture of saline, 0.25% bupivacaine HCl with epinephrine, and EXPAREL. 20 mL of EXPAREL was diluted with 20 mL of saline and 10 mL of 0.25% bupivacaine HCl with epinephrine*

POD, postoperative day; SA, shoulder arthroplasty.

*The use of EXPAREL in combination with epinephrine is not part of the approved label.